micromagnetic-microfluidic blood cleansing device
Joined: Dec 2009
09-12-2009, 06:09 PM
Sepsis is a lethal disease caused by a systemic microbial infection that spreads via the bloodstream to overwhelm the bodyâ„¢s defenses. Current therapeutic approaches are often suboptimal, in part, because they do not fully eliminate the pathogen, and hence the source of deadly toxins. Here we describe an extracorporeal blood cleansing device to selectively remove pathogens from contaminated blood and thereby enhance the patientâ„¢s response to antibiotic therapy. Immunomagnetic micro beads were modified to create magnetic opsonins that were used to cleanse flowing human whole blood of Candida albicans fungi, a leading cause of sepsis-related deaths. The micromagneticâ€œmicrofluidic blood cleansing device generates magnetic field gradients across vertically stacked channels to enable continuous and high throughput separation of fungi from flowing whole blood. A multiplexed version of the device containing four parallel channels achieved over 80% clearance of fungi from contaminated blood at a flow rate of 20 mL/h in a single pass, a rate 1000 times faster than a previously described prototype micromagneticâ€œmicrofluidic cell separation system. These results provide the first proof-of principle that a multiplexed micromagneticâ€œmicrofluidic separation system can be used to cleanse pathogens from flowing human blood at a rate and separation efficiency that is relevant for clinical applications.
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