ppt on single photon emission computed tomography
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08-02-2011, 06:14 PM

i wnt ppt on single photon emission its very urgent please send me as soon as possible
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21-03-2012, 09:39 AM

i need a full report and documentation on spect(single photon emission computed tomography...i need it n itz urgent...can ny 1 plz help me out...mail me akash.chaithanya@gmail.com
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21-03-2012, 10:02 AM

to get information about the topic "single photon emission computed tomography" full report ppt and related topic refer the link bellow





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03-07-2012, 03:26 PM

Single-photon emission computed tomography

.docx   Single-photon emission.docx (Size: 41.42 KB / Downloads: 22)


The basic technique requires injection of a gamma-emitting radioisotope (called radionuclide) into the bloodstream of the patient. On occasion, the radioisotope is a simple soluble dissolved ion, such as a radioisotope of gallium(III), which happens to also have chemical properties that allow it to be concentrated in ways of medical interest for disease detection. However, most of the time in SPECT, a marker radioisotope, which is of interest only for its radioactive properties, has been attached to a specific ligand to create a radioligand, which is of interest for its chemical binding properties to certain types of tissues. This marriage allows the combination of ligand and radioisotope (theradiopharmaceutical) to be carried and bound to a place of interest in the body, which then (due to the gamma-emission of the isotope) allows the ligand concentration to be seen by a gamma-camera.

HMPAO brain 3D SPECT for neuropsychiatric diagnosis

Most SPECT scanner workstations can render the 2D slices in a variety of formats. In a 3D Surface View, the cortical surface of the brain is reconstructed from the 2D slices. Holes or defects in the surface of the brain actually represent decreases in perfusion, which may be related to decreases in neuronal activity.[2] In a 3D Active View the interior of the brain is displayed as a lattice gridwork. Daniel Amen, a California-based physician who has utilized 3D SPECT scanning heavily in his medical practice, has standardized 3D Active Views such that average activity is shown in a blue color, higher activity is shown in red, and very high activity is shown in white.[3] Some utility of brain HMAPO 3D SPECT scan in neuropsychiatric diagnosis and management has been found.[4].


SPECT can be used to complement any gamma imaging study, where a true 3D representation can be helpful, e.g., tumor imaging, infection (leukocyte) imaging, thyroid imaging or bone imaging.
Because SPECT permits accurate localisation in 3D space, it can be used to provide information about localised function in internal organs, such as functional cardiac or brain imaging.

Functional brain imaging

Because blood flow in the brain is tightly coupled to local brain metabolism and energy use, the 99mTc-HMPAO tracer (as well as the similar 99mTc-EC tracer) is used to assess brain metabolism regionally, in an attempt to diagnose and differentiate the different causal pathologies of dementia. Meta-analysis of many reported studies suggests that SPECT with this tracer is about 74% sensitive at diagnosing Alzheimer's disease vs. 81% sensitivity for clinical exam (mental testing, etc.). More recent studies have shown the accuracy of SPECT in Alzheimer's diagnosis may be as high as 88%.[6] In meta analysis, SPECT was superior to clinical exam and clinical criteria (91% vs. 70%) in being able to differentiate Alzheimer's disease from vascular dementias.[7] This latter ability relates to SPECT's imaging of local metabolism of the brain, in which the patchy loss of cortical metabolism seen in multiple strokes differs clearly from the more even or "smooth" loss of non-occipital cortical brain function typical of Alzheimer's disease.


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